Chemistry vs. bacteria, # 11. Pride comes before a fall
Both the UK and the US greet M&B 693 or sulfapyridine with much enthusiasm. In the war years, this message about the sulfas is a much-needed piece of good news. Project ‘100 years of antibiotics’ Episode 9. In the crossfire Episode 10. International recognition Episode 11. Pride comes before a fall Episode 12. Lessons learned
Chemistry vs. bacteria, # 10. International recognition
In 1937 already, the medical profession in the United Kingdom, France and the United States recognizes the major importance of the sulfanilamide and the other sulfas; for different reasons in each country. Project ‘100 years of antibiotics’ Episode 8. The success of the sulfas; with a black rim Episode 9. In the crossfire Episode 10.
Chemistry vs. bacteria, # 9. In the crossfire
We haven’t yet told the whole story about the sulfas in Germany during WW II. For further reading we recommend the book by John E. Lesch, already referred to: The First Miracle Drugs, How the sulfa drugs transformed medicine. In much detail, the author tells how endangered from many sides and careful, main characters of
Chemistry vs. bacteria, # 8. The success of the sulfas; with a black rim
After Prontosil, the sulfas make a breakthrough. The success really takes off in WW II, in particular in the forces of Germany and its allies. But the success has a major black rim. IG Farben is not just a major German chemical cartel and the leading organization in the rational and multidisciplinary approach to medicines
Chemistry vs. bacteria, episode 7. Aspirin
According to one version of the history of Aspirin, German chemist Felix Hoffmann who works with Bayer, has it all sorted out in 1897. Felix is 29 years old. As the story goes, his father suffers from arthritis and after having been administered the new substance, he lives through his first pain-free night in many
Chemistry vs. bacteria, episode 6. Gerhard Domagk and Prontosil, the first sulfa drug
The success of Salvarsan leads Paul Ehrlich to believe that he will quickly be able to eliminate many other pathogens. In 1914, he addresses the 7th International Medical Congress in London. In paraphrase he says: ‘All countries in the world are represented here, witnessing that all borders between nations have been eliminated in scientific cooperation.’
100 years of chemistry vs. bacteria, episode 5. A colourful foreplay
Many of our readers will know the prominent role played by Germany in the development and the many applications of synthetic dyes. They will also know the name of Justus von Liebig, the ‘founding father’ of coal tar research. This marks the start of industrial chemistry; dyes are made from coal tar and are the
Who are we? The microbiome revisted
In the column ‘There is no such thing as an individual’ we mentioned the influence of the microorganisms in our bodies on our development. But biologists have already gone much further along this path. Our microbiome, the living guests in our bodies, number in the millions; among them bacteria, moulds and phages (although phages cannot
on: 5 March 2021